| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CASP10 |
| Gene ID: | 843 |
| Uniprot ID: | CASPA_HUMAN |
| Immunogen Region: | 230-505 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-505 of human Caspase-10 (NP_116759.2). |
| Immunogen Sequence: | ESWQNKHAGSNGNRATNGAP SLVSRGMQGASANTLNSETS TKRAAVYRMNRNHRGLCVIV NNHSFTSLKDRQGTHKDAEI LSHVFQWLGFTVHIHNNVTK VEMEMVLQKQKCNPAHADGD CFVFCILTHGRFGAVYSSDE ALIPIREIMSHFTALQCPRL AEKPKLFFIQACQGEEIQPS VSIEADALNPEQAPTSLQDS IPAEADFLLGLATVPGYVSF RHVEEGSWYIQSLCNHLKK |
| Tissue Specificity | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. |
| Post Translational Modifications | Cleavage by granzyme B and autocatalytic activity generate the two active subunits. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. |
| Protein Name | Caspase-10 Casp-10 Apoptotic Protease Mch-4 Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 Flice2 Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 |
| Database Links | Reactome: R-HSA-6803207 Reactome: R-HSA-75157 Reactome: R-HSA-75158 Reactome: R-HSA-933543 |
| Alternative Antibody Names | Anti-Caspase-10 antibody Anti-Casp-10 antibody Anti-Apoptotic Protease Mch-4 antibody Anti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibody Anti-Flice2 antibody Anti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibody Anti-CASP10 antibody Anti-MCH4 antibody |
Information sourced from Uniprot.org