| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CAMSAP2 (1-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CAMSAP2 |
| Gene ID: |
23271 |
| Uniprot ID: |
CAMP2_HUMAN |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CAMSAP2 (NP_982284.1). |
| Immunogen Sequence: |
MGDAADPREMRKTFIVPAIK PFDHYDFSRAKIACNLAWLV AKAFGTENVPEELQEPFYTD QYDQEHIKPPVVNLLLSAEL YCRAGSLILKSDAAKPLLGH DAVIQALAQKGLYVTDQEKL VTERDLHKKPIQMSAHLAMI DTLMMAYTVE |
| Function | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubule polymerization. Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes. Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation. Through the microtubule cytoskeleton, regulates the autophagosome transport. |
| Protein Name | Calmodulin-Regulated Spectrin-Associated Protein 2Calmodulin-Regulated Spectrin-Associated Protein 1-Like Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonGolgi ApparatusCilium Basal BodyAssociated With The Minus-End Of Microtubules And Also Detected At The CentrosomesDecorates The Minus-End Of Microtubules By Decreasing The Rate Of Tubulin Incorporation And Remaining BoundThe Length Of Camsap2-Decorated Stretches On The Minus-End Of Microtubules Depends On Mapre1/Eb1 And Mapre3/Eb3Which Promote Elongation Of Camsap2-Decorated Microtubule StretchesRecruited To The Golgi Apparatus By Akap9 And Pde4dip Isoform 13/Mmg8/SmyleIn NeuronsLocalizes To The Minus-End Of Microtubules In Axon And Dendrites |
| Alternative Antibody Names | Anti-Calmodulin-Regulated Spectrin-Associated Protein 2 antibodyAnti-Calmodulin-Regulated Spectrin-Associated Protein 1-Like Protein 1 antibodyAnti-CAMSAP2 antibodyAnti-CAMSAP1L1 antibodyAnti-KIAA1078 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
