| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CALR (18-203) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CALR |
| Gene ID: |
811 |
| Uniprot ID: |
CALR_HUMAN |
| Immunogen Region: |
18-203 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 18-203 of human Calreticulineticulin (NP_004334.1). |
| Immunogen Sequence: |
EPAVYFKEQFLDGDGWTSRW IESKHKSDFGKFVLSSGKFY GDEEKDKGLQTSQDARFYAL SASFEPFSNKGQTLVVQFTV KHEQNIDCGGGYVKLFPNSL DQTDMHGDSEYNIMFGPDIC GPGTKKVHVIFNYKGKNVLI NKDIRCKDDEFTHLYTLIVR PDNTYEVKIDNSQVESGSLE DDWDFL |
| Function | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy. |
| Protein Name | CalreticulinCrp55CalregulinEndoplasmic Reticulum Resident Protein 60Erp60HacbpGrp60 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-168316Reactome: R-HSA-3000480Reactome: R-HSA-3000484Reactome: R-HSA-381183Reactome: R-HSA-901042Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum LumenCytoplasmCytosolSecretedExtracellular SpaceExtracellular MatrixCell SurfaceSarcoplasmic Reticulum LumenCytoplasmic VesicleSecretory VesicleCortical GranuleCytolytic GranuleAlso Found In Cell Surface (T Cells)Cytosol And Extracellular MatrixDuring Oocyte Maturation And After Parthenogenetic Activation Accumulates In Cortical GranulesIn Pronuclear And Early Cleaved Embryos Localizes Weakly To Cytoplasm Around Nucleus And More Strongly In The Region Near The CortexIn Cortical Granules Of Non-Activated OocytesIs Exocytosed During The Cortical Reaction In Response To Oocyte Activation |
| Alternative Antibody Names | Anti-Calreticulin antibodyAnti-Crp55 antibodyAnti-Calregulin antibodyAnti-Endoplasmic Reticulum Resident Protein 60 antibodyAnti-Erp60 antibodyAnti-Hacbp antibodyAnti-Grp60 antibodyAnti-CALR antibodyAnti-CRTC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
