| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNA2D4 (992-1115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA2D4 |
| Gene ID: |
93589 |
| Uniprot ID: |
CA2D4_HUMAN |
| Immunogen Region: |
992-1115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 992-1115 of human CACNA2D4 (NP_758952.4). |
| Immunogen Sequence: |
AKSVFHHSHKHKKQDPLQPC DTEYPVFVYQPAIREANGIV ECGPCQKVFVVQQIPNSNLL LLVTDPTCDCSIFPPVLQEA TEVKYNASVKCDRMRSQKLR RRPDSCHAFHPEENAQDCGG ASDT |
| Tissue Specificity | Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). |
| Post Translational Modifications | May be proteolytically processed into subunits alpha-2-4 and delta-4 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-4Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-4 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-4 - Voltage-Dependent Calcium Channel Subunit Delta-4 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-4 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-4 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-4 - Voltage-Dependent Calcium Channel Subunit Delta-4 antibodyAnti-CACNA2D4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
