| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C11orf30 (1153-1322) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EMSY |
| Gene ID: |
56946 |
| Uniprot ID: |
EMSY_HUMAN |
| Immunogen Region: |
1153-1322 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1322 of human C11orf30 (NP_064578.2). |
| Immunogen Sequence: |
SLMEAQIDTNVEHMIVDPPK KALATSMLTGEAGSLPSTHM VVAGMANSTPQQQKCRESCS SPSTVGSSLTTRKIDPPAVP ATGQFMRIQNVGQKKAEESP AEIIIQAIPQYAIPCHSSSN VVVEPSGLLELNNFTSQQLD DEETAMEQDIDSSTEDGTEP SPSQSSAERS |
| Post Translational Modifications | O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. |
| Function | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. |
| Protein Name | Brca2-Interacting Transcriptional Repressor Emsy |
| Cellular Localisation | NucleusLocalizes To Dna Damage Markers In Irradiated CellsSuggesting That It Participates In Dna Repair Process |
| Alternative Antibody Names | Anti-Brca2-Interacting Transcriptional Repressor Emsy antibodyAnti-EMSY antibodyAnti-C11orf30 antibodyAnti-GL002 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
