| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BTN3A1 |
| Gene ID: | 11119 |
| Uniprot ID: | BT3A1_HUMAN |
| Immunogen Region: | 40-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-250 of human BTN3A1 (NP_008979.3). |
| Immunogen Sequence: | ILAMVGEDADLPCHLFPTMS AETMELKWVSSSLRQVVNVY ADGKEVEDRQSAPYRGRTSI LRDGITAGKAALRIHNVTAS DSGKYLCYFQDGDFYEKALV ELKVAALGSDLHVDVKGYKD GGIHLECRSTGWYPQPQIQW SNNKGENIPTVEAPVVADGV GLYAVAASVIMRGSSGEGVS CTIRSSLLGLEKTASISIAD PFFRSAQRWIA |
| Tissue Specificity | Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. |
| Protein Name | Butyrophilin Subfamily 3 Member A1Cd Antigen Cd277 |
| Database Links | Reactome: R-HSA-8851680 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Butyrophilin Subfamily 3 Member A1 antibodyAnti-Cd Antigen Cd277 antibodyAnti-BTN3A1 antibodyAnti-BTF5 antibody |
Information sourced from Uniprot.org