| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BLOC1S2 |
| Gene ID: | 282991 |
| Uniprot ID: | BL1S2_HUMAN |
| Immunogen Region: | 44-142 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-142 of human BLOC1S2 (NP_776170.2). |
| Immunogen Sequence: | MFSKMATYLTGELTATSEDY KLLENMNKLTSLKYLEMKDI AINISRNLKDLNQKYAGLQP YLDQINVIEEQVAALEQAAY KLDAYSKKLEAKYKKLEKR |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level). |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 2Bloc-1 Subunit 2Centrosome-Associated Protein |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLysosome MembraneLocalizes To The Centrosomes In A Microtubule-Dependent Manner |
| Alternative Antibody Names | Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 2 antibodyAnti-Bloc-1 Subunit 2 antibodyAnti-Centrosome-Associated Protein antibodyAnti-BLOC1S2 antibodyAnti-BLOS2 antibodyAnti-CEAP antibody |
Information sourced from Uniprot.org
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