| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BLOC1S2 (44-142) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BLOC1S2 |
| Gene ID: |
282991 |
| Uniprot ID: |
BL1S2_HUMAN |
| Immunogen Region: |
44-142 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 44-142 of human BLOC1S2 (NP_776170.2). |
| Immunogen Sequence: |
MFSKMATYLTGELTATSEDY KLLENMNKLTSLKYLEMKDI AINISRNLKDLNQKYAGLQP YLDQINVIEEQVAALEQAAY KLDAYSKKLEAKYKKLEKR |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level). |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 2Bloc-1 Subunit 2Centrosome-Associated Protein |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLysosome MembraneLocalizes To The Centrosomes In A Microtubule-Dependent Manner |
| Alternative Antibody Names | Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 2 antibodyAnti-Bloc-1 Subunit 2 antibodyAnti-Centrosome-Associated Protein antibodyAnti-BLOC1S2 antibodyAnti-BLOS2 antibodyAnti-CEAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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