| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 1Bloc-1 Subunit 1Gcn5-Like Protein 1Protein Rt14 |
| Database Links | Reactome: R-HSA-432720Reactome: R-HSA-432722 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixCytoplasmCytosolLysosome Membrane |
| Alternative Antibody Names | Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 1 antibodyAnti-Bloc-1 Subunit 1 antibodyAnti-Gcn5-Like Protein 1 antibodyAnti-Protein Rt14 antibodyAnti-BLOC1S1 antibodyAnti-BLOS1 antibodyAnti-GCN5L1 antibodyAnti-RT14 antibody |
Information sourced from Uniprot.org
