| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BIRC3 |
| Gene ID: | 330 |
| Uniprot ID: | BIRC3_HUMAN |
| Immunogen Region: | 100-604 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-130 of human cIAP2 (NP_001156.1). |
| Immunogen Sequence: | NSVNNLEATSQPTFPSSVTN STHSLLPGTEN |
| Tissue Specificity | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. |
| Post Translational Modifications | Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 3 Apoptosis Inhibitor 2 Api2 Cellular Inhibitor Of Apoptosis 2 C-Iap2 Iap Homolog C Inhibitor Of Apoptosis Protein 1 Hiap-1 Hiap1 Ring Finger Protein 49 Ring-Type E3 Ubiquitin Transferase Birc3 Tnfr2-Traf-Signaling Complex Protein 1 |
| Database Links | Reactome: R-HSA-168638 Reactome: R-HSA-168927 Reactome: R-HSA-5213460 Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5668541 Reactome: R-HSA-5675482 Reactome: R-HSA-5676594 Reactome: R-HSA-5689880 Reactome: R-HSA-937041 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Baculoviral Iap Repeat-Containing Protein 3 antibody Anti-Apoptosis Inhibitor 2 antibody Anti-Api2 antibody Anti-Cellular Inhibitor Of Apoptosis 2 antibody Anti-C-Iap2 antibody Anti-Iap Homolog C antibody Anti-Inhibitor Of Apoptosis Protein 1 antibody Anti-Hiap-1 antibody Anti-Hiap1 antibody Anti-Ring Finger Protein 49 antibody Anti-Ring-Type E3 Ubiquitin Transferase Birc3 antibody Anti-Tnfr2-Traf-Signaling Complex Protein 1 antibody Anti-BIRC3 antibody Anti-API2 antibody Anti-MIHC antibody Anti-RNF49 antibody |
Information sourced from Uniprot.org