| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Baculoviral Iap Repeat-Containing Protein 2 (331-420) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BIRC2 |
| Gene ID: |
329 |
| Uniprot ID: |
BIRC2_HUMAN |
| Immunogen Region: |
331-420 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 331-420 of human cIAP1 (NP_001157.1). |
| Immunogen Sequence: |
PRCEFLIRMKGQEFVDEIQG RYPHLLEQLLSTSDTTGEEN ADPPIIHFGPGESSSEDAVM MNTPVVKSALEMGFNRDLVK QTVQSKILTT |
| Tissue Specificity | Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. |
| Post Translational Modifications | Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates the protein. |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 2Cellular Inhibitor Of Apoptosis 1C-Iap1Iap Homolog BInhibitor Of Apoptosis Protein 2Hiap-2Hiap2Ring Finger Protein 48Ring-Type E3 Ubiquitin Transferase Birc2Tnfr2-Traf-Signaling Complex Protein 2 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-168638Reactome: R-HSA-168927Reactome: R-HSA-5213460Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5668541Reactome: R-HSA-5675482Reactome: R-HSA-5676594Reactome: R-HSA-5689880Reactome: R-HSA-937041 |
| Cellular Localisation | CytoplasmNucleusAgents That Induce Either The Extrinsic Or Intrinsic Apoptotic Pathways Promote Its Redistribution From The Nuclear Compartment To The Cytoplasmic CompartmentAssociated With The Midbody In Telophase CellsAnd Found Diffusely In The Nucleus Of Interphase Cells |
| Alternative Antibody Names | Anti-Baculoviral Iap Repeat-Containing Protein 2 antibodyAnti-Cellular Inhibitor Of Apoptosis 1 antibodyAnti-C-Iap1 antibodyAnti-Iap Homolog B antibodyAnti-Inhibitor Of Apoptosis Protein 2 antibodyAnti-Hiap-2 antibodyAnti-Hiap2 antibodyAnti-Ring Finger Protein 48 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Birc2 antibodyAnti-Tnfr2-Traf-Signaling Complex Protein 2 antibodyAnti-BIRC2 antibodyAnti-API1 antibodyAnti-MIHB antibodyAnti-RNF48 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
