| Post Translational Modifications | Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. Filensin C-terminal fragment: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433. Filensin N-terminal fragment: Acetylated at Ala-42 following proteolytic cleavage at Leu-41. |
| Function | Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability. |
| Protein Name | FilensinBeaded Filament Structural Protein 1Lens Fiber Cell Beaded-Filament Structural Protein Cp 115Cp115Lens Intermediate Filament-Like HeavyLifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell Cortex |
| Alternative Antibody Names | Anti-Filensin antibodyAnti-Beaded Filament Structural Protein 1 antibodyAnti-Lens Fiber Cell Beaded-Filament Structural Protein Cp 115 antibodyAnti-Cp115 antibodyAnti-Lens Intermediate Filament-Like Heavy antibodyAnti-Lifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment antibodyAnti-BFSP1 antibody |
Information sourced from Uniprot.org
