| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Filensin (494-544 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BFSP1 |
| Gene ID: |
631 |
| Uniprot ID: |
BFSP1_HUMAN |
| Immunogen Region: |
494-544 aa |
| Specificity: |
This antibody detects endogenous levels of BFSP1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human BFSP1 at the amino acid range 494-544 |
| Post Translational Modifications | Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. Filensin C-terminal fragment: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433. Filensin N-terminal fragment: Acetylated at Ala-42 following proteolytic cleavage at Leu-41. |
| Function | Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability. |
| Protein Name | FilensinBeaded Filament Structural Protein 1Lens Fiber Cell Beaded-Filament Structural Protein Cp 115Cp115Lens Intermediate Filament-Like HeavyLifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell Cortex |
| Alternative Antibody Names | Anti-Filensin antibodyAnti-Beaded Filament Structural Protein 1 antibodyAnti-Lens Fiber Cell Beaded-Filament Structural Protein Cp 115 antibodyAnti-Cp115 antibodyAnti-Lens Intermediate Filament-Like Heavy antibodyAnti-Lifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment antibodyAnti-BFSP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
