| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BAZ1A (1347-1556) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BAZ1A |
| Gene ID: |
11177 |
| Uniprot ID: |
BAZ1A_HUMAN |
| Immunogen Region: |
1347-1556 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1347-1556 of human BAZ1A (NP_038476.2). |
| Immunogen Sequence: |
VFVELLSPRRKRRGRKSANN TPENSPNFPNFRVIATKSSE QSRSVNIASKLSLQESESKR RCRKRQSPEPSPVTLGRRSS GRQGGVHELSAFEQLVVELV RHDDSWPFLKLVSKIQVPDY YDIIKKPIALNIIREKVNKC EYKLASEFIDDIELMFSNCF EYNPRNTSEAKAGTRLQAFF HIQAQKLGLHVTPSNVDQVS TPPAAKKSRI |
| Tissue Specificity | Highly expressed in testis and at low or undetectable levels in other tissues analyzed. |
| Function | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression. |
| Protein Name | Bromodomain Adjacent To Zinc Finger Domain Protein 1aAtp-Dependent Chromatin-Remodeling ProteinAtp-Utilizing Chromatin Assembly And Remodeling Factor 1Hacf1Chrac Subunit Acf1Williams Syndrome Transcription Factor-Related Chromatin-Remodeling Factor 180Wcrf180Hwalp1 |
| Cellular Localisation | NucleusLocalizes To Pericentric HeterochromatinMay Target The Chrac Complex To HeterochromatinLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Bromodomain Adjacent To Zinc Finger Domain Protein 1a antibodyAnti-Atp-Dependent Chromatin-Remodeling Protein antibodyAnti-Atp-Utilizing Chromatin Assembly And Remodeling Factor 1 antibodyAnti-Hacf1 antibodyAnti-Chrac Subunit Acf1 antibodyAnti-Williams Syndrome Transcription Factor-Related Chromatin-Remodeling Factor 180 antibodyAnti-Wcrf180 antibodyAnti-Hwalp1 antibodyAnti-BAZ1A antibodyAnti-ACF1 antibodyAnti-WCRF180 antibodyAnti-HSPC317 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
