| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-B4GALT4 (35-344) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
B4GALT4 |
| Gene ID: |
8702 |
| Uniprot ID: |
B4GT4_HUMAN |
| Immunogen Region: |
35-344 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 35-344 of human B4GALT4 (NP_003769.1). |
| Immunogen Sequence: |
VGAIQEIPKAKEFMANFHKT LILGKGKTLTNEASTKKVEL DNCPSVSPYLRGQSKLIFKP DLTLEEVQAENPKVSRGRYR PQECKALQRVAILVPHRNRE KHLMYLLEHLHPFLQRQQLD YGIYVIHQAEGKKFNRAKLL NVGYLEALKEENWDCFIFHD VDLVPENDFNLYKCEEHPKH LVVGRNSTGYRLRYSGYFGG VTALSREQFFKVNGFSNNYW GWGGEDDDLRLRVELQRMK |
| Tissue Specificity | Highest expression is observed in placenta, pancreas, kidney and heart. Expressed in corneal epithelial cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units ->3Galbeta1->4(6-sulfoGlcNAcbeta)1-> and ->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1-> within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide. |
| Protein Name | Beta-1 -4-Galactosyltransferase 4Beta-1 -4-Galtase 4Beta4gal-T4B4gal-T4Beta-N-Acetylglucosaminyl-Glycolipid Beta-1 -4-GalactosyltransferaseLactotriaosylceramide Beta-1 -4-GalactosyltransferaseN-Acetyllactosamine SynthaseNal SynthaseUdp-Gal -Beta-Glcnac Beta-1 -4-Galactosyltransferase 4Udp-Galactose -Beta-N-Acetylglucosamine Beta-1 -4-Galactosyltransferase 4 |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecreted |
| Alternative Antibody Names | Anti-Beta-1 -4-Galactosyltransferase 4 antibodyAnti-Beta-1 -4-Galtase 4 antibodyAnti-Beta4gal-T4 antibodyAnti-B4gal-T4 antibodyAnti-Beta-N-Acetylglucosaminyl-Glycolipid Beta-1 -4-Galactosyltransferase antibodyAnti-Lactotriaosylceramide Beta-1 -4-Galactosyltransferase antibodyAnti-N-Acetyllactosamine Synthase antibodyAnti-Nal Synthase antibodyAnti-Udp-Gal -Beta-Glcnac Beta-1 -4-Galactosyltransferase 4 antibodyAnti-Udp-Galactose -Beta-N-Acetylglucosamine Beta-1 -4-Galactosyltransferase 4 antibodyAnti-B4GALT4 antibodyAnti-UNQ552 antibodyAnti-PRO1109 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
