| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AXIN2 (9-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AXIN2 |
| Gene ID: |
8313 |
| Uniprot ID: |
AXIN2_HUMAN |
| Immunogen Region: |
9-600 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 9-600 of human AXIN2 (NP_004646.3). |
| Immunogen Sequence: |
CLPDPSSSFREDAPRPPVPG EEGETPPCQPGVGKGQVTKP MPVSSNTRRNEDGLGEPEGR ASPDSPLTRWTKSLHSLLGD QDGAYLFRTFLEREKCVDTL DFWFACNGFRQMNLKDTKTL RVAKAIYKRYIENNSIVSKQ LKPATKTYIRDGIKKQQIDS IMFDQAQTEIQSVMEENAYQ MFLTSDIYLEYVRSGGENTA YMSNGGLGSLKVVCGYLPTL NEEEEWTCADFKCKLSPTV |
| Tissue Specificity | Expressed in brain and lymphoblast. |
| Post Translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Protein Name | Axin-2Axin-Like ProteinAxilAxis Inhibition Protein 2Conductin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4411364Reactome: R-HSA-4641257Reactome: R-HSA-5689880 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Axin-2 antibodyAnti-Axin-Like Protein antibodyAnti-Axil antibodyAnti-Axis Inhibition Protein 2 antibodyAnti-Conductin antibodyAnti-AXIN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
