| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AURKC (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AURKC |
| Gene ID: |
6795 |
| Uniprot ID: |
AURKC_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AURKC (NP_001015878.1). |
| Immunogen Sequence: |
MSSPRAVVQLGKAQPAGEEL ATANQTAQQPSSPAMRRLTV DDFEIGRPLGKGKFGNVYLA RLKESHFIVALKVLFKSQIE KEGLEHQLRREIEIQAHLQH |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase CAurora 3Aurora/Ipl1-Related Kinase 3Ark-3Aurora-Related Kinase 3Aurora/Ipl1/Eg2 Protein 2Serine/Threonine-Protein Kinase 13Serine/Threonine-Protein Kinase Aurora-C |
| Cellular Localisation | NucleusChromosomeCentromereCytoplasmCytoskeletonSpindleDistributes In The Condensed Chromosomes During Prophase To MetaphaseAfter Entering AnaphaseThere Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone MicrotubulesAnd Finally Remains In The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Aurora Kinase C antibodyAnti-Aurora 3 antibodyAnti-Aurora/Ipl1-Related Kinase 3 antibodyAnti-Ark-3 antibodyAnti-Aurora-Related Kinase 3 antibodyAnti-Aurora/Ipl1/Eg2 Protein 2 antibodyAnti-Serine/Threonine-Protein Kinase 13 antibodyAnti-Serine/Threonine-Protein Kinase Aurora-C antibodyAnti-AURKC antibodyAnti-AIE2 antibodyAnti-AIK3 antibodyAnti-AIRK3 antibodyAnti-ARK3 antibodyAnti-STK13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
