Anti-ATXN1 antibody (Internal) (STJ72025)

SKU:
STJ72025-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Dog/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ATXN1 (Internal) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ATXN1
Gene ID: 6310
Uniprot ID: ATX1_HUMAN
Immunogen Region: Internal
Accession Number: NP_000323.2
Specificity: Reported variant NP_000323.2 and NP_001121636.1 represent identical protein.
Immunogen Sequence: DLEVQQATHREASP
Post Translational Modifications Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
Function Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development.
Protein Name Ataxin-1
Spinocerebellar Ataxia Type 1 Protein
Cellular Localisation Cytoplasm
Nucleus
Colocalizes With Usp7 In The Nucleus
Alternative Antibody Names Anti-Ataxin-1 antibody
Anti-Spinocerebellar Ataxia Type 1 Protein antibody
Anti-ATXN1 antibody
Anti-ATX1 antibody
Anti-SCA1 antibody

Information sourced from Uniprot.org

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