| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Proteolytically cleaved by CASP3, CASP6 and CASP7. Phosphorylated at Ser-1116 likely by PRKCA.this creates a functional di-leucine motif that is sufficient for endocytosis. |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids. |
| Protein Name | Phospholipid-Transporting Atpase IgAtpase IqAtpase Class Vi Type 11cP4-Atpase Flippase Complex Alpha Subunit Atp11c |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEarly Endosome MembraneRecycling Endosome MembraneEfficient Exit From The Endoplasmic Reticulum Requires The Presence Of Tmem30aInternalized Via Clathrin-Dependent Endocytosis In Response To Ca(2+) Signaling Induced By G-Protein Coupled Serotonin And Histamine Receptors |
| Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Ig antibodyAnti-Atpase Iq antibodyAnti-Atpase Class Vi Type 11c antibodyAnti-P4-Atpase Flippase Complex Alpha Subunit Atp11c antibodyAnti-ATP11C antibodyAnti-ATPIG antibodyAnti-ATPIQ antibody |
Information sourced from Uniprot.org
