| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASXL1 (70-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASXL1 |
| Gene ID: |
171023 |
| Uniprot ID: |
ASXL1_HUMAN |
| Immunogen Region: |
70-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 70-250 of human ASXL1 (NP_056153.2). |
| Immunogen Sequence: |
LFYKLPGRISLFTLKKDALQ WSRHPATVEGEEPEDTADVE SCGSNEASTVSGENDVSLDE TSSNASCSTESQSRPLSNPR DSYRASSQANKQKKKTGVML PRVVLTPLKVNGAHVESASG FSGCHADGESGSPSSSSSGS LALGSAAIRGQAEVTQDPAP LLRGFRKPATGQMKRNRGEE I |
| Tissue Specificity | Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes. |
| Post Translational Modifications | Ubiquitinated by TRIP12, leading to its subsequent degradation following binding N(6)-methyladenosine methylated DNA (m6A). |
| Function | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing. |
| Protein Name | Polycomb Group Protein Asxl1Additional Sex Combs-Like Protein 1 |
| Database Links | Reactome: R-HSA-5689603 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Protein Asxl1 antibodyAnti-Additional Sex Combs-Like Protein 1 antibodyAnti-ASXL1 antibodyAnti-KIAA0978 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
