| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASTL (24-431) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASTL |
| Gene ID: |
431705 |
| Uniprot ID: |
ASTL_HUMAN |
| Immunogen Region: |
24-431 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3). |
| Immunogen Sequence: |
APLASSCAGACGTSFPDGLT PEGTQASGDKDIPAINQGLI LEETPESSFLIEGDIIRPSP FRLLSATSNKWPMGGSGVVE VPFLLSSKYDEPSRQVILEA LAEFERSTCIRFVTYQDQRD FISIIPMYGCFSSVGRSGGM QVVSLAPTCLQKGRGIVLHE LMHVLGFWHEHTRADRDRYI RVNWNEILPGFEINFIKSQS SNMLTPYDYSSVMHYGRLAF SRRGLPTITPLWAPSVHIG |
| Function | Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. |
| Protein Name | Astacin-Like MetalloendopeptidaseOocyte AstacinOvastacinZp2-Proteinase |
| Cellular Localisation | CytoplasmCell MembraneCytoplasmic VesicleSecretory VesicleCortical GranuleProbably Exocytosed From Cortical Granules During Post-FertilizationDetected Throughout The Ooplasm Of Germinal Vesicle Stage Oocytes In Early Bilaminar Secondary Follicles At Postnatal (Pn) Day 3Detected In The Microvillar Domain Of The Oolemma In Arrested Ovulated Secondary Oocytes And In The First Polar Body Prior To FertilizationUpon FertilizationDetected In The Perivitelline Space (Pvs) And Occasionally On The Oolemma In 2-Cell Through Morulae StagesColocalizes With Spaca3 At The Microvillar Domain Of The Oolemma And In The Perivitelline Space (Pvs) |
| Alternative Antibody Names | Anti-Astacin-Like Metalloendopeptidase antibodyAnti-Oocyte Astacin antibodyAnti-Ovastacin antibodyAnti-Zp2-Proteinase antibodyAnti-ASTL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
