| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASIP |
| Gene ID: | 434 |
| Uniprot ID: | ASIP_HUMAN |
| Immunogen Region: | 23-132 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2). |
| Immunogen Sequence: | HLPPEEKLRDDRSLRSNSSV NLLDVPSVSIVALNKKSKQI GRKAAEKKRSSKKEASMKKV VRPRTPLSAPCVATRNSCKP PAPACCDPCASCQCRFFRSA CSCRVLSLNC |
| Tissue Specificity | Widely expressed at low levels. Highly expressed in the skin. Expressed in adipose tissue. |
| Function | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| Protein Name | Agouti-Signaling ProteinAspAgouti Switch Protein |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Agouti-Signaling Protein antibodyAnti-Asp antibodyAnti-Agouti Switch Protein antibodyAnti-ASIP antibodyAnti-AGTI antibodyAnti-AGTIL antibodyAnti-ASP antibody |
Information sourced from Uniprot.org