| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASIC2 (120-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASIC2 |
| Gene ID: |
40 |
| Uniprot ID: |
ASIC2_HUMAN |
| Immunogen Region: |
120-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human ASIC2 (NP_001085.2). |
| Immunogen Sequence: |
NLQIPDPHLADPSVLEALRQ KANFKHYKPKQFSMLEFLHR VGHDLKDMMLYCKFKGQECG HQDFTTVFTKYGKCYMFNSG EDGKPLLTTVKGGTGNGLEI MLDIQQDEYLPIWGETEETT FEAGVKVQIHSQSEPPFIQE LGFGVAPGFQTFVATQEQRL TYLPPPWGECRSSEMGLDFF PVYSITACRIDCETRYIVEN CNCRMVHMPGDAPFCTPEQH KECAEPALGLLAEKDSNYC |
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Protein Name | Acid-Sensing Ion Channel 2Asic2Amiloride-Sensitive Brain Sodium ChannelAmiloride-Sensitive Cation Channel 1 - NeuronalAmiloride-Sensitive Cation Channel Neuronal 1Brain Sodium Channel 1Bnc1Bnac1Mammalian Degenerin HomologMdeg |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At The Plasma Membrane Of NeuronsIn The Soma And Punctated Peripheral Processes |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 2 antibodyAnti-Asic2 antibodyAnti-Amiloride-Sensitive Brain Sodium Channel antibodyAnti-Amiloride-Sensitive Cation Channel 1 - Neuronal antibodyAnti-Amiloride-Sensitive Cation Channel Neuronal 1 antibodyAnti-Brain Sodium Channel 1 antibodyAnti-Bnc1 antibodyAnti-Bnac1 antibodyAnti-Mammalian Degenerin Homolog antibodyAnti-Mdeg antibodyAnti-ASIC2 antibodyAnti-ACCN antibodyAnti-ACCN1 antibodyAnti-BNAC1 antibodyAnti-MDEG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
