| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARHGAP22 |
| Gene ID: | 58504 |
| Uniprot ID: | RHG22_HUMAN |
| Immunogen Region: | 510-650 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-650 of human ARHGAP22 (NP_001242953.1). |
| Immunogen Sequence: | NVPAPGLVPGIPSVASMAWS GASSSESSVGGSLSSCTACR ASDSSARSSLHTDWALEPSP LPSSSEDPKSLDLDHSMDEA GAGASNSEPSEPDSPTREHA RRSEALQGLVTELRAELCRQ RTEYERSVKRIEEGSADLRK R |
| Function | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. |
| Protein Name | Rho Gtpase-Activating Protein 22Rho-Type Gtpase-Activating Protein 22 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmNucleusMainly CytoplasmicSome Fraction Is Nuclear |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 22 antibodyAnti-Rho-Type Gtpase-Activating Protein 22 antibodyAnti-ARHGAP22 antibodyAnti-RHOGAP2 antibody |
Information sourced from Uniprot.org