| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARFIP2 (1-110) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARFIP2 |
| Gene ID: |
23647 |
| Uniprot ID: |
ARFP2_HUMAN |
| Immunogen Region: |
1-110 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human ARFIP2 (NP_036534.1). |
| Immunogen Sequence: |
MTDGILGKAATMEIPIHGNG EARQLPEDDGLEQDLQQVMV SGPNLNETSIVSGGYGGSGD GLIPTGSGRHPSHSTTPSGP GDEVARGIAGEKFDIVKKWG INTYKCTKQL |
| Function | Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. |
| Protein Name | Arfaptin-2Adp-Ribosylation Factor-Interacting Protein 2Partner Of Rac1Por1 |
| Database Links | Reactome: R-HSA-6811440 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network Membrane |
| Alternative Antibody Names | Anti-Arfaptin-2 antibodyAnti-Adp-Ribosylation Factor-Interacting Protein 2 antibodyAnti-Partner Of Rac1 antibodyAnti-Por1 antibodyAnti-ARFIP2 antibodyAnti-POR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
