| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APOBEC3D (207-386) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APOBEC3DUniprot ID=ABC3D_HUMAN" |
| Immunogen Region: |
207-386 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 207-386 of human APOBEC3D (NP_689639.2). |
| Immunogen Sequence: |
AMYPHIFYFHFKNLLKACGR NESWLCFTMEVTKHHSAVFR KRGVFRNQVDPETHCHAERC FLSWFCDDILSPNTNYEVTW YTSWSPCPECAGEVAEFLAR HSNVNLTIFTARLCYFWDTD YQEGLCSLSQEGASVKIMGY KDFVSCWKNFVYSDDEPFKP WKGLQTNFRLLKRRLREILQ |
| Tissue Specificity | Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Inhibits also the mobility of LTR and non-LTR retrotransposons. (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3dA3dA3de |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3d antibodyAnti-A3d antibodyAnti-A3de antibodyAnti-APOBEC3D antibodyAnti-APOBEC3DE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
