| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKTIP |
| Gene ID: | 64400 |
| Uniprot ID: | AKTIP_HUMAN |
| Immunogen Region: | 1-292 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human AKTIP (NP_071921.1). |
| Immunogen Sequence: | MNPFWSMSTSSVRKRSEGEE KTLTGDVKTSPPRTAPKKQL PSIPKNALPITKPTSPAPAA QSTNGTHASYGPFYLEYSLL AEFTLVVKQKLPGVYVQPSY RSALMWFGVIFIRHGLYQDG VFKFTVYIPDNYPDGDCPRL VFDIPVFHPLVDPTSGELDV KRAFAKWRRNHNHIWQVLMY ARRVFYKIDTASPLNPEAAV LYEKDIQLFKSKVVDSVKVC TARLFDQPKIEDPYAISFS |
| Function | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. |
| Protein Name | Akt-Interacting ProteinFt1Fused Toes Protein Homolog |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Akt-Interacting Protein antibodyAnti-Ft1 antibodyAnti-Fused Toes Protein Homolog antibodyAnti-AKTIP antibodyAnti-FTS antibody |
Information sourced from Uniprot.org