| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AKR1D1 (1-326) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AKR1D1 |
| Gene ID: |
6718 |
| Uniprot ID: |
AK1D1_HUMAN |
| Immunogen Region: |
1-326 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human AKR1D1 (NP_005980.1). |
| Immunogen Sequence: |
MDLSAASHRIPLSDGNSIPI IGLGTYSEPKSTPKGACATS VKVAIDTGYRHIDGAYIYQN EHEVGEAIREKIAEGKVRRE DIFYCGKLWATNHVPEMVRP TLERTLRVLQLDYVDLYIIE VPMAFKPGDEIYPRDENGKW LYHKSNLCATWEAMEACKDA GLVKSLGVSNFNRRQLELIL NKPGLKHKPVSNQVECHPYF TQPKLLKFCQQHDIVITAYS PLGTSRNPIWVNVSSPPLL |
| Tissue Specificity | Highly expressed in liver. Expressed in testis and weakly in colon. |
| Function | Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). |
| Protein Name | Aldo-Keto Reductase Family 1 Member D13-Oxo-5-Beta-Steroid 4-DehydrogenaseDelta(4-3-Ketosteroid 5-Beta-ReductaseDelta(4-3-Oxosteroid 5-Beta-Reductase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member D1 antibodyAnti-3-Oxo-5-Beta-Steroid 4-Dehydrogenase antibodyAnti-Delta(4-3-Ketosteroid 5-Beta-Reductase antibodyAnti-Delta(4-3-Oxosteroid 5-Beta-Reductase antibodyAnti-AKR1D1 antibodyAnti-SRD5B1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
