Anti-AKR1C1 antibody (1-323) (STJ114973)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AKR1C1 (1-323) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AKR1C1 |
| Gene ID | 1645 |
| Uniprot ID | AK1C1_HUMAN |
| Immunogen Region | 1-323 |
| Immunogen Sequence | MDSKYQCVKLNDGHFMPVLG FGTYAPAEVPKSKALEATKL AIEAGFRHIDSAHLYNNEEQ VGLAIRSKIADGSVKREDIF YTSKLWCNSHRPELVRPALE RSLKNLQLDYVDLYLIHFPV SVKPGEEVIPKDENGKILFD TVDLCATWEAVEKCKDAGLA KSIGVSNFNRRQLEMILNKP GLKYKPVCNQVECHPYFNQR KLLDFCKSKDIVLVAYSALG SHREEPWVDPNSPVLLEDP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2). |
Additional Info
| Tissue Specificity | Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain. |
| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C1 20-Alpha-Hydroxysteroid Dehydrogenase20-Alpha-HsdChlordecone Reductase Homolog HakrcDihydrodiol Dehydrogenase 1Dd1High-Affinity Hepatic Bile Acid-Binding ProteinHbab |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807Reactome: R-HSA-975634Reactome: R-HSA-9757110 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member C1 antibodyAnti-20-Alpha-Hydroxysteroid Dehydrogenase antibodyAnti-20-Alpha-Hsd antibodyAnti-Chlordecone Reductase Homolog Hakrc antibodyAnti-Dihydrodiol Dehydrogenase 1 antibodyAnti-Dd1 antibodyAnti-High-Affinity Hepatic Bile Acid-Binding Protein antibodyAnti-Hbab antibodyAnti-AKR1C1 antibodyAnti-DDH antibodyAnti-DDH1 antibody |
Information sourced from Uniprot.org