STJ71517 (0. 1µg/ml) staining of Human Tonsil lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-AID antibody (N-Term) (STJ71517)

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STJ71517-100
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-AID (N-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:1000.
WB: Approx 26kDa band observed in Human Tonsil lysates (calculated MW of 24.0kDa according to NP_065712.1). Recommended concentration: 0.1-0.3µg/ml. Primary incubation was 1 hour.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: AICDA
Gene ID: 57379
Uniprot ID: AICDA_HUMAN
Immunogen Region: N-Term
Accession Number: NP_065712.1
Immunogen Sequence: RRKFLYQFKNVR
Post Translational Modifications Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126.
Function Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Protein Name Single-Stranded Dna Cytosine Deaminase
Activation-Induced Cytidine Deaminase
Aid
Cytidine Aminohydrolase
Database Links Reactome: R-HSA-9821002
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Predominantly Cytosolic
In The Presence Of Mcm3ap/Ganp
Relocalizes To The Nucleus
Alternative Antibody Names Anti-Single-Stranded Dna Cytosine Deaminase antibody
Anti-Activation-Induced Cytidine Deaminase antibody
Anti-Aid antibody
Anti-Cytidine Aminohydrolase antibody
Anti-AICDA antibody
Anti-AID antibody

Information sourced from Uniprot.org

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