| Function | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis. |
| Protein Name | Cytosolic Carboxypeptidase 1Atp/Gtp-Binding Protein 1Nervous System Nuclear Protein Induced By Axotomy Protein 1 HomologProtein Deglutamylase Ccp1 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmCytosolNucleusMitochondrionLocalizes In Both The Cytoplasm And Nuclei Of Interphase And Dividing Cells |
| Alternative Antibody Names | Anti-Cytosolic Carboxypeptidase 1 antibodyAnti-Atp/Gtp-Binding Protein 1 antibodyAnti-Nervous System Nuclear Protein Induced By Axotomy Protein 1 Homolog antibodyAnti-Protein Deglutamylase Ccp1 antibodyAnti-AGTPBP1 antibodyAnti-CCP1 antibodyAnti-KIAA1035 antibodyAnti-NNA1 antibody |
Information sourced from Uniprot.org
