| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGRP |
| Gene ID: | 181 |
| Uniprot ID: | AGRP_HUMAN |
| Immunogen Region: | 21-132 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1). |
| Immunogen Sequence: | AQMGLAPMEGIRRPDQALLP ELPGLGLRAPLKKTTAEQAE EDLLQEAQALAEVLDLQDRE PRSSRRCVRLHESCLGQQVP CCDPCATCYCRFFNAFCYCR KLGTAMNPCSRT |
| Tissue Specificity | Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. |
| Protein Name | Agouti-Related Protein |
| Database Links | Reactome: R-HSA-9615017 |
| Cellular Localisation | SecretedGolgi Apparatus Lumen |
| Alternative Antibody Names | Anti-Agouti-Related Protein antibodyAnti-AGRP antibodyAnti-AGRT antibodyAnti-ART antibody |
Information sourced from Uniprot.org