| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ADCY6 (13-27) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.59µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100-1:200 ICC: 1:100-1:200 IF: 1:100-1:200 CFM: 1:100-1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Adcy6 |
| Gene ID: | 25289 |
| Uniprot ID: | ADCY6_RAT |
| Immunogen Region: | 13-27 |
| Immunogen: | Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH. |
| Tissue Specificity | Detected in brain and kidney. Detected in vascular smooth muscle cells. |
| Post Translational Modifications | Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli. |
| Protein Name | Adenylate Cyclase Type 6 Atp Pyrophosphate-Lyase 6 Adenylate Cyclase Type Vi Acvi Adenylyl Cyclase 6 Ac6 Ca(2+-Inhibitable Adenylyl Cyclase |
| Database Links | Reactome: R-RNO-163615 Reactome: -RNO-170660 Reactome: -RNO-170670 Reactome: -RNO-400042 Reactome: -RNO-418597 Reactome: -RNO-5610787 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Cilium Stereocilium |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 6 antibody Anti-Atp Pyrophosphate-Lyase 6 antibody Anti-Adenylate Cyclase Type Vi antibody Anti-Acvi antibody Anti-Adenylyl Cyclase 6 antibody Anti-Ac6 antibody Anti-Ca(2+-Inhibitable Adenylyl Cyclase antibody Anti-Adcy6 antibody |
Information sourced from Uniprot.org