| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADCK3 (1-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COQ8A |
| Gene ID: |
56997 |
| Uniprot ID: |
COQ8A_HUMAN |
| Immunogen Region: |
1-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ADCK3 (NP_064632.2). |
| Immunogen Sequence: |
MAAILGDTIMVAKGLVKLTQ AAVETHLQHLGIGGELIMAA RALQSTAVEQIGMFLGKVQG QDKHEEYFAENFGGPEGEFH FSVPHAAGASTDFSSASAPD QSAPPSLGHAHSEGPAPAYV ASGPFREAGFPGQASSPLGR ANGRLFANPRDSFSAMGFQR RFFHQDQSPVGGLTAEDIEK ARQAKARPENKQHKQTLSEH ARERKVPVTRIGRLANFGGL |
| Tissue Specificity | Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. |
| Function | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP. |
| Protein Name | Atypical Kinase Coq8a - MitochondrialChaperone Activity Of Bc1 Complex-LikeChaperone-Abc1-LikeCoenzyme Q Protein 8aAarf Domain-Containing Protein Kinase 3 |
| Cellular Localisation | MitochondrionMembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atypical Kinase Coq8a - Mitochondrial antibodyAnti-Chaperone Activity Of Bc1 Complex-Like antibodyAnti-Chaperone-Abc1-Like antibodyAnti-Coenzyme Q Protein 8a antibodyAnti-Aarf Domain-Containing Protein Kinase 3 antibodyAnti-COQ8A antibodyAnti-ADCK3 antibodyAnti-CABC1 antibodyAnti-PP265 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Emerin/Emerin/EMD knockout (KO) 293T cells, using [KO Validated] Emerin/EMD Rabbit polyclonal antibody (STJ119989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98774/382822/STJ119989_1__22320.1713151321.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Emerin/Emerin/EMD knockout (KO) 293T cells, using [KO Validated] Emerin/EMD Rabbit polyclonal antibody (STJ119989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")