• Immunofluorescence analysis of PC-12 cells using ADAMTS1 Rabbit monoclonal antibody (STJ11105226) at a dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of NIH/3T3 cells using ADAMTS1 Rabbit monoclonal antibody (STJ11105226) at a dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of HeLa cells using ADAMTS1 Rabbit monoclonal antibody (STJ11105226) at a dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of 293F cells using ADAMTS1 Rabbit monoclonal antibody (STJ11105226) at a dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-ADAMTS1 antibody (50-174) [S5226RM] (STJ11105226)

SKU:
STJ11105226

£146.50 - £639.50
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Host: Rabbit
Applications: IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1 (50-174) is suitable for use in Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S5226RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADAMTS1
Gene ID: 9510
Uniprot ID: ATS1_HUMAN
Immunogen Region: 50-174
Immunogen: Recombinant fusion protein containing a sequen cecorresponding to amino acids 50-174 of human ADAMTS1 (NP_008919.3).
Immunogen Sequence: LGRPSEEDEELVVPELERAP GHGTTRLRLHAFDQQLDLEL RPDSSFLAPGFTLQNVGRKS GSETPLPETDLAHCFYSGTV NGDPSSAAALSLCEGVRGAF YLLGEAYFIQPLPAASERLA TAAPG
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1
Adam-Ts 1
Adam-Ts1
Adamts-1
Meth-1
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1 antibody
Anti-Adam-Ts 1 antibody
Anti-Adam-Ts1 antibody
Anti-Adamts-1 antibody
Anti-Meth-1 antibody
Anti-ADAMTS1 antibody
Anti-KIAA1346 antibody
Anti-METH1 antibody

Information sourced from Uniprot.org

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