| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Disintegrin and metalloproteinase domain-containing protein 15 (50-130 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM15 |
| Gene ID: |
8751 |
| Uniprot ID: |
ADA15_HUMAN |
| Immunogen Region: |
50-130 aa |
| Specificity: |
ADA15 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 50-130 |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs. |
| Function | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 15Adam 15Metalloprotease Rgd Disintegrin ProteinMetalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15Mdc-15Metargidin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-8941237 |
| Cellular Localisation | Endomembrane SystemSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionCell ProjectionCiliumFlagellumCytoplasmic VesicleSecretory VesicleAcrosomeThe Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late EndosomeThe Pro-Protein Is The Major Detectable Form On The Cell SurfaceWhereas The Majority Of The Protein In The Cell Is Processed |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 15 antibodyAnti-Adam 15 antibodyAnti-Metalloprotease Rgd Disintegrin Protein antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 antibodyAnti-Mdc-15 antibodyAnti-Metargidin antibodyAnti-ADAM15 antibodyAnti-MDC15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
