| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Disintegrin and metalloproteinase domain-containing protein 15 (50-130 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAM15 |
| Gene ID: | 8751 |
| Uniprot ID: | ADA15_HUMAN |
| Immunogen Region: | 50-130 aa |
| Specificity: | ADA15 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 50-130 |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs. |
| Function | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 15 Adam 15 Metalloprotease Rgd Disintegrin Protein Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 Mdc-15 Metargidin |
| Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-8941237 |
| Cellular Localisation | Endomembrane System Single-Pass Type I Membrane Protein Cell Junction Adherens Junction Cell Projection Cilium Flagellum Cytoplasmic Vesicle Secretory Vesicle Acrosome The Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late Endosome The Pro-Protein Is The Major Detectable Form On The Cell Surface Whereas The Majority Of The Protein In The Cell Is Processed |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 15 antibody Anti-Adam 15 antibody Anti-Metalloprotease Rgd Disintegrin Protein antibody Anti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 antibody Anti-Mdc-15 antibody Anti-Metargidin antibody Anti-ADAM15 antibody Anti-MDC15 antibody |
Information sourced from Uniprot.org