• Western blot analysis of HEPG2-UV cells using Acetyl-CRM1 (K568) Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000
  • Western blot analysis of HepG2-UV, mouse brain cells using Acetyl-CRM1 (K568) Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000

Anti-Acetyl-XPO1-Lys568 antibody (Internal) (STJ97225)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal antibody anti-Acetyl-Exportin-1-Lys568 (Internal) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: XPO1
Gene ID: 7514
Uniprot ID: XPO1_HUMAN
Immunogen Region: Internal
Specificity: Acetyl-XPO1-Lys568 polyclonal antibody (Exportin-1) binds to endogenous Exportin-1 at the amino acid region Internal.
Immunogen: Synthesized acetyl-peptide derived from the Internal region of human CRM1 around the acetylation site of K568.
Function Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Protein Name Exportin-1
Chromosome Region Maintenance 1 Protein Homolog
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-165054
Reactome: R-HSA-168333
Reactome: R-HSA-2173788
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-3769402
Reactome: R-HSA-450520
Reactome: R-HSA-5663220
Reactome: R-HSA-5687128
Reactome: R-HSA-68877
Reactome: R-HSA-69273
Reactome: R-HSA-9634638
Reactome: R-HSA-9648025
Reactome: R-HSA-9707616
Cellular Localisation Cytoplasm
Cajal Body
Located In The Nucleoplasm
Cajal Bodies And Nucleoli
Shuttles Between The Nucleus/Nucleolus And The Cytoplasm
Alternative Antibody Names Anti-Exportin-1 antibody
Anti-Exp1 antibody
Anti-Chromosome Region Maintenance 1 Protein Homolog antibody
Anti-XPO1 antibody
Anti-CRM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance