| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCG5 |
| Gene ID: | 64240 |
| Uniprot ID: | ABCG5_HUMAN |
| Immunogen Region: | 350-450 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ABCG5 (NP_071881.1). |
| Immunogen Sequence: | TLPMVPFKTKDSPGVFSKLG VLLRRVTRNLVRNKLAVITR LLQNLIMGLFLLFFVLRVRS NVLKGAIQDRVGLLYQFVGA TPYTGMLNAVNLFPVLRAVS D |
| Tissue Specificity | Strongly expressed in the liver, lower levels in the small intestine and colon. |
| Post Translational Modifications | N-glycosylated. |
| Function | ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 5Sterolin-1 |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-5679090Reactome: R-HSA-5679096Reactome: R-HSA-9029569 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 5 antibodyAnti-Sterolin-1 antibodyAnti-ABCG5 antibody |
Information sourced from Uniprot.org