| Tissue Specificity | Expressed specifically in the brain and the eye. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 4 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneEndosome Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 4 antibodyAnti-ABCG4 antibodyAnti-WHITE2 antibody |
Information sourced from Uniprot.org
