| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCD4 (100-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCD4 |
| Gene ID: |
5826 |
| Uniprot ID: |
ABCD4_HUMAN |
| Immunogen Region: |
100-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1). |
| Immunogen Sequence: |
DQFTCNLLYVSWRKDLTEHL HRLYFRGRAYYTLNVLRDDI DNPDQRISQDVERFCRQLSS MASKLIISPFTLVYYTYQCF QSTGWLGPVSIFGYFILGTV VNKTLMGPIVMKLVHQEKLE GDFRFKHMQIRVNAEPAAFY RAGHVEHMRTDRRLQRLLQT QRELMSKELWLYIGINTFDY L |
| Tissue Specificity | Ubiquitous. |
| Function | Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane. |
| Protein Name | Lysosomal Cobalamin Transporter Abcd4Atp-Binding Cassette Sub-Family D Member 4Pmp70-Related ProteinP70rPeroxisomal Membrane Protein 1-LikePxmp1-LPeroxisomal Membrane Protein 69Pmp69 |
| Database Links | Reactome: R-HSA-5683329Reactome: R-HSA-9758881Reactome: R-HSA-9758890 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLysosome MembraneTargeted By Lmbrd1 Lysosomal Chaperone To The Lysosomal Membrane |
| Alternative Antibody Names | Anti-Lysosomal Cobalamin Transporter Abcd4 antibodyAnti-Atp-Binding Cassette Sub-Family D Member 4 antibodyAnti-Pmp70-Related Protein antibodyAnti-P70r antibodyAnti-Peroxisomal Membrane Protein 1-Like antibodyAnti-Pxmp1-L antibodyAnti-Peroxisomal Membrane Protein 69 antibodyAnti-Pmp69 antibodyAnti-ABCD4 antibodyAnti-PXMP1L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
