Anti-ABCA7 antibody (2050-2130aa) (STJ190579)

SKU:
STJ190579

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody Anti-Phospholipid-transporting ATPase (2050-2130aa) is suitable for use in Western Blot and ELISA.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purification: ABCA7 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Concentration: 1 mg/ml
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA7
Gene ID: 10347
Uniprot ID: ABCA7_HUMAN
Immunogen Region: 2050-2130aa
Specificity: ABCA7 polyclonal antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from human ABCA7 protein.
Post Translational Modifications N-glycosylated.
Function Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylserine over phosphatidylcholine. Plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing. Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients.
Protein Name Phospholipid-Transporting Atpase Abca7
Abca-Ssn
Atp-Binding Cassette Sub-Family A Member 7
Autoantigen Ss-N
Macrophage Abc Transporter
Database Links Reactome: R-HSA-1369062
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Early Endosome Membrane
Cytoplasm
Cell Projection
Ruffle Membrane
Phagocytic Cup
Localizes To Cell Membrane Ruffles And Phagocytic Cups Of Macrophages Stimulated With C1q Or Apoptotic Cells
Localizes To The Cytoplasm Of Resting Macrophages
Probably In Golgi And Endosomes
Localizes To The Apical Brush Border Of Cells In The Proximal Tubules Of Kidney
Isoform 2: Cytoplasm
Endoplasmic Reticulum
May Localize To The Endoplasmic Reticulum
Alternative Antibody Names Anti-Phospholipid-Transporting Atpase Abca7 antibody
Anti-Abca-Ssn antibody
Anti-Atp-Binding Cassette Sub-Family A Member 7 antibody
Anti-Autoantigen Ss-N antibody
Anti-Macrophage Abc Transporter antibody
Anti-ABCA7 antibody

Information sourced from Uniprot.org

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