Anti-A2M antibody (1100-1180 C-Term) (STJ93980)


Current Stock:
Host: Rabbit
Applications: IHC-P, IF-P, ELISA
Reactivity: Human, Rat, Mouse
Short Description: Rabbit polyclonal antibody anti-Alpha-2-Macroglobulin (1100-1180 C-Term) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: A2M
Gene ID: 2
Uniprot ID: A2MG_HUMAN
Immunogen Region: 1100-1180 C-Term
Specificity: A2M polyclonal antibody (Alpha-2-Macroglobulin) binds to endogenous Alpha-2-Macroglobulin at the amino acid region 1100-1180 C-Term.
Immunogen: Synthesized peptide derived from Macroglobulin Alpha-2. at amino acid range: 1100-1180
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Protein Name Alpha-2-Macroglobulin
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-140837
Reactome: R-HSA-1474228
Reactome: R-HSA-8963896
Cellular Localisation Secreted
Alternative Antibody Names Anti-Alpha-2-Macroglobulin antibody
Anti-Alpha-2-M antibody
Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody
Anti-A2M antibody
Anti-CPAMD5 antibody
Anti-FWP007 antibody

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