• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY5/6 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HeLa cells, using ADCY5/6 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-A Cyclase V/VI antibody (900-980 C-Term) (STJ91398)


Current Stock:
Host: Rabbit
Applications: IHC-P, IF, ICC, ELISA
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal antibody anti-Adenylate cyclase type 6 and Adenylate cyclase type 5 (900-980 C-Term) is suitable for use in Immunohistochemistry, Immunofluorescence, Immunocytochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADCY5
Gene ID: 111
Immunogen Region: 900-980 C-Term
Specificity: A Cyclase V/VI polyclonal antibody (Adenylate cyclase type 6 and Adenylate cyclase type 5) binds to endogenous Adenylate cyclase type 6 and Adenylate cyclase type 5 at the amino acid region 900-980 C-Term.
Immunogen: The antiserum was produced against synthesized peptide derived from human ADCY5/6 at amino acid range 931-980
Post Translational Modifications Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA at Ser-662 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC at Ser-556, Ser-662 and Thr-919 inhibits catalytic activity.
Function Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
Protein Name Adenylate Cyclase Type 6
Atp Pyrophosphate-Lyase 6
Adenylate Cyclase Type Vi
Adenylyl Cyclase 6
Ca(2+-Inhibitable Adenylyl Cyclase
Database Links Reactome: R-HSA-163359
Reactome: R-HSA-163615
Reactome: R-HSA-164378
Reactome: R-HSA-170660
Reactome: R-HSA-170670
Reactome: R-HSA-381676
Reactome: R-HSA-400042
Reactome: R-HSA-418555
Reactome: R-HSA-418594
Reactome: R-HSA-418597
Reactome: R-HSA-432040
Reactome: R-HSA-5610787
Reactome: R-HSA-9660821
Reactome: R-HSA-9664323
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Alternative Antibody Names Anti-Adenylate Cyclase Type 6 antibody
Anti-Atp Pyrophosphate-Lyase 6 antibody
Anti-Adenylate Cyclase Type Vi antibody
Anti-Adenylyl Cyclase 6 antibody
Anti-Ca(2+-Inhibitable Adenylyl Cyclase antibody
Anti-ADCY6 antibody
Anti-KIAA0422 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance