| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ADCY7 Blocking Peptide for STJ502059 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Adcy7 |
| Gene ID: |
11513 |
| Uniprot ID: |
ADCY7_MOUSE |
| Specificity: |
This blocking peptide is recommended for use in combination with ADCY7 antibody, STJ502059 |
| Immunogen: |
Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein. |
| Tissue Specificity | Most abundant in heart, spleen and lung. |
| Post Translational Modifications | Phosphorylated by PRKCD. |
| Function | Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells. |
| Peptide Name | Adenylate Cyclase Type 7Atp Pyrophosphate-Lyase 7Adenylate Cyclase Type ViiAdenylyl Cyclase 7 |
| Database Links | Reactome: R-MMU-163615Reactome: -MMU-170660Reactome: -MMU-170670Reactome: -MMU-418597Reactome: -MMU-5610787 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Adenylate Cyclase Type 7 proteinAtp Pyrophosphate-Lyase 7 proteinAdenylate Cyclase Type Vii proteinAdenylyl Cyclase 7 proteinAdcy7 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
