ADCY6 Blocking Peptide for STJ502072 peptide (STJ504517)

SKU:
STJ504517-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ADCY6 Blocking Peptide for STJ502072 is synthetically produced from the 13-27 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Adcy6
Gene ID: 25289
Uniprot ID: ADCY6_RAT
Immunogen Region: 13-27
Specificity: This blocking peptide is recommended for use in combination with ADCY6 antibody, STJ502072
Immunogen: Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH. Sequence: DERKTAWGERNGQKR
Tissue Specificity Detected in brain and kidney. Detected in vascular smooth muscle cells.
Post Translational Modifications Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity.
Function Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
Peptide Name Adenylate Cyclase Type 6
Atp Pyrophosphate-Lyase 6
Adenylate Cyclase Type Vi
Acvi
Adenylyl Cyclase 6
Ac6
Ca(2+-Inhibitable Adenylyl Cyclase
Database Links Reactome: R-RNO-163615
Reactome: -RNO-170660
Reactome: -RNO-170670
Reactome: -RNO-400042
Reactome: -RNO-418597
Reactome: -RNO-5610787
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium
Stereocilium
Alternative Peptide Names Adenylate Cyclase Type 6 protein
Atp Pyrophosphate-Lyase 6 protein
Adenylate Cyclase Type Vi protein
Acvi protein
Adenylyl Cyclase 6 protein
Ac6 protein
Ca(2+-Inhibitable Adenylyl Cyclase protein
Adcy6 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance