| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ABHD2 Positive Control for STJ500017 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Abhd2 |
| Gene ID: |
54608 |
| Uniprot ID: |
ABHD2_MOUSE |
| Specificity: |
This is positive control is recommended for use in combination with ABHD2 antibody STJ500017. |
| Tissue Specificity | Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart. |
| Function | Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration. |
| Peptide Name | Monoacylglycerol Lipase Abhd22-Arachidonoylglycerol HydrolaseAbhydrolase Domain-Containing Protein 2AcetylesteraseLung Alpha/Beta Hydrolase 2Mmlabh2Triacylglycerol Lipase |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosome MembraneAbsent From The Sperm Flagellum |
| Alternative Peptide Names | Monoacylglycerol Lipase Abhd2 protein2-Arachidonoylglycerol Hydrolase proteinAbhydrolase Domain-Containing Protein 2 proteinAcetylesterase proteinLung Alpha/Beta Hydrolase 2 proteinMmlabh2 proteinTriacylglycerol Lipase proteinAbhd2 proteinLabh-2 proteinLabh2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
