Rat PFKL (Phosphofructokinase, Liver) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017800)

Rat PFKL (Phosphofructokinase, Liver) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017800)

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STJE0017800
£518.50 - £712.50
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.58ng/mL
Detection Limit: 1.56-100ng/mL
Short Description : This PFKL Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Pfkl
Gene ID: 25741
Uniprot ID: PFKAL_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation.
Function Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.
Protein Name Atp-Dependent 6-Phosphofructokinase - Liver Type
Atp-Pfk
Pfk-L
6-Phosphofructokinase Type B
Phosphofructo-1-Kinase Isozyme B
Pfk-B
Phosphohexokinase
Database Links Reactome: R-RNO-6798695
Reactome: -RNO-70171
Cellular Localisation Cytoplasm
Alternative ELISA Names Atp-Dependent 6-Phosphofructokinase - Liver Type ELISA kit
Atp-Pfk ELISA kit
Pfk-L ELISA kit
6-Phosphofructokinase Type B ELISA kit
Phosphofructo-1-Kinase Isozyme B ELISA kit
Pfk-B ELISA kit
Phosphohexokinase ELISA kit
Pfkl ELISA kit
Pfk-l ELISA kit
output

Information sourced from Uniprot.org

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