| Tissue Specificity | Highly expressed in skeletal muscle. Also expressed in leg tendons/ligaments and osteoblasts. In long bones and teeth, present in knee joint and periodontal ligaments (at protein level). |
| Post Translational Modifications | |
| Function | Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C. May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. |
| Protein Name | OsteocrinMusclin Cleaved Into - Processed Osteocrin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Osteocrin ELISA kitMusclin Cleaved Into - Processed Osteocrin ELISA kitOstn ELISA kit |
| output | |
Information sourced from Uniprot.org
