| Tissue Specificity | |
| Post Translational Modifications | Sumoylated by SUMO1 at Lys-289 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. |
| Function | Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. |
| Protein Name | Nuclear Receptor Subfamily 5 Group A Member 2Ftz-F1 BetaLiver Receptor Homolog 1Lrh-1 |
| Database Links | Reactome: R-RNO-383280Reactome: -RNO-4090294Reactome: -RNO-9018519 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Nuclear Receptor Subfamily 5 Group A Member 2 ELISA kitFtz-F1 Beta ELISA kitLiver Receptor Homolog 1 ELISA kitLrh-1 ELISA kitNr5a2 ELISA kit |
| output | |
Information sourced from Uniprot.org
