Tissue Specificity | Localized in brain and is highly enriched in the Purkinje cell layer in cerebellum. |
Post Translational Modifications | Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. |
Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. |
Protein Name | Excitatory Amino Acid Transporter 2Glt-1Sodium-Dependent Glutamate/Aspartate Transporter 2Glut-RSolute Carrier Family 1 Member 2 |
Database Links | Reactome: R-RNO-210455Reactome: -RNO-210500Reactome: -RNO-425393 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative ELISA Names | Excitatory Amino Acid Transporter 2 ELISA kitGlt-1 ELISA kitSodium-Dependent Glutamate/Aspartate Transporter 2 ELISA kitGlut-R ELISA kitSolute Carrier Family 1 Member 2 ELISA kitSlc1a2 ELISA kitEaat2 ELISA kitGlt1 ELISA kit |
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Information sourced from Uniprot.org