| Tissue Specificity | Adrenal zona fasciculata/reticularis. |
| Post Translational Modifications | |
| Function | A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone. Could also be involved in the androgen metabolic pathway. |
| Protein Name | Cytochrome P450 11b1 - MitochondrialCypxib1Cytochrome P450(11 Beta-DsCytochrome P450c11Steroid 11-Beta-Hydroxylase - Cyp11b1 |
| Database Links | |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane Protein |
| Alternative ELISA Names | Cytochrome P450 11b1 - Mitochondrial ELISA kitCypxib1 ELISA kitCytochrome P450(11 Beta-Ds ELISA kitCytochrome P450c11 ELISA kitSteroid 11-Beta-Hydroxylase - Cyp11b1 ELISA kitCyp11b1 ELISA kitCyp11b-1 ELISA kit |
| output | |
Information sourced from Uniprot.org
